Gloria A Preston, PhD
 | Associate Professor of Medicine |
CONTACT INFORMATION
| Phone: 919-966-2561 Fax: Email: gloria_preston@med.unc.edu |
EDUCATION
| Ph.D., University of Tennessee Graduate School of Biomedical Sciences / Oak Ridge National Laboratories, 1991 |
RESEARCH SUMMARY
| Evidence of pathogenic effects has been found for antineutrophil cytoplasmic autoantibodies (ANCA), most notably those with antimyeloperoxidase or antiproteinase-3 specificity, in small-vessel vasculitides (Wegener's granulomatosis, Churg-Strauss syndrome, and microscopic polyangiitis). The disease process is thought to involve complex interactions between genetic and environmental factors leading to a humoral autoimmune response against neutrophilic components. My work explores potential pathomechanistic explanations of ANCA-associated diseases. Specifically, what is the origin of autoantibodies and how do environmental exposures contribute; do the autoantibody/granulocyte interactions cause pathogenic changes in granulocyte functions, including changes in gene expression profiles; and what factors are primary in the genesis of resultant endothelial lesions of the vascular endothelium? |
PUBLICATIONS
| Search the publications on PubMed using Preston+G* as search criteria. |
